Afamitresgene autoleucel (afami-cel), a newly approved gene therapy, is designed to treat adults with advanced or metastatic synovial sarcoma. This therapy is tailored for patients whose tumors express the MAGE-A4 antigen and who have certain HLA antigens (HLA-A*02 subtypes). Afami-cel works by engineering a patient’s own T cells to target and attack MAGE-A4-expressing cancer cells.
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